The Isolation of Volatile Organic Compounds as Noninvasive Early Markers of Pulmonary Oxygen Toxicity in Swine
| Autor: | Angela L. Senese, David P. Regis, Aaron A. Hall, Richard T. Mahon, William A. Cronin |
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| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Oxygen deficient business.industry chemistry.chemical_element medicine.disease Biochemistry Oxygen chemistry Current practice Anesthesia Genetics medicine Biomarker (medicine) Arterial blood Pulmonary Injury OXYGEN EXPOSURE business Molecular Biology Oxygen toxicity Biotechnology |
| Zdroj: | The FASEB Journal. 29 |
| ISSN: | 1530-6860 0892-6638 |
| DOI: | 10.1096/fasebj.29.1_supplement.678.2 |
| Popis: | Purpose: Pulmonary oxygen toxicity (PO2T) is a concern for any patient or warfighter exposed to oxygen enriched atmospheres for an extended amount of time. While current practice is to limit increased oxygen exposure; there are clinical and operational scenarios where higher oxygen levels must be used and PO2T becomes a concern. The purpose of the current study is to develop a non-invasive breath exhalate based biomarker which can detect PO2T prior to clinical manifestations of the disease. Methods: Male Yorkshire swine (20-30 kg) were placed into custom plexi-glass runs and randomized to air (n=10) or 100% oxygen (n=10) for 72 hours. Breath exhalate samples, arterial blood gas samples, and vital signs were assessed every 12 hours. At the end of the 72 hour exposure animals were euthanized and the lungs were processed for histological injury and wet/dry ratios. Results: Swine exposed to the oxygen enriched atmosphere developed a variable pulmonary injury consistent with PO2T. Histologically there was evid... |
| Databáze: | OpenAIRE |
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