Primary Biliary Cirrhosis
| Autor: | Leslie B. Lilly, John L. Gollan, Carl L. Berg |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
0303 health sciences
Pathology medicine.medical_specialty education.field_of_study Population Human leukocyte antigen Biology Major histocompatibility complex medicine.disease 3. Good health Complement system Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Primary biliary cirrhosis Immunology medicine biology.protein Immunology and Allergy 030211 gastroenterology & hepatology Pharmacology (medical) Antibody education 030304 developmental biology |
| Zdroj: | Clinical Immunotherapeutics. 5:420-437 |
| ISSN: | 1172-7039 |
| DOI: | 10.1007/bf03259338 |
| Popis: | Primary biliary cirrhosis is a well-characterised disorder of autoimmune origin whose exact pathogenesis remains poorly understood. Population studies have suggested an association with human leucocyte antigen (HLA)-DR8, and patients are universally positive for antimitochondrial antibodies; however, the clinical relevance of these observations is unclear. Other putative autoantigens have been proposed. Numerous abnormalities throughout the immune system as well as in complement pathways have been characterised, and major histocompatibility complex (MHC) expression on biliary epithelial cells is increased. |
| Databáze: | OpenAIRE |
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