Allograft Injury and Outcomes in African American Lung Transplant Recipients
| Autor: | J. Matthews, Aldo Iacono, Anne Brown, I. Timofte, Ilker Tunc, A. Marishta, Kiran K. Khush, C. Marboe, Sean Agbor-Enoh, A. Charya, U. Fideli, Pali D. Shah, Moon Kyoo Jang, H.A. Valantine, Yanqin Yang, Steven D. Nathan, K. Bhatti, Helen Luikart, G. Berry, J.B. Orens, H. Kong |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine medicine.medical_specialty medicine.medical_treatment Kidney transplant Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Lung transplantation Prospective cohort study African american Transplantation Lung Plasma samples business.industry Tacrolimus surgical procedures operative 030104 developmental biology medicine.anatomical_structure 030228 respiratory system Baseline characteristics Surgery Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Journal of Heart and Lung Transplantation. 39:S55-S56 |
| ISSN: | 1053-2498 |
| Popis: | Purpose African American patients (AA) have poorer outcomes than White patients (W) after heart and kidney transplant. Little is known about differential outcomes in lung transplantation (LTx). This study compares allograft injury and chronic allograft dysfunction (CLAD) in AA and W LTx. Methods The 469 LTx enrolled in two multicenter prospective cohort studies were categorized by self-reported race. Outcomes: Time from transplant to CLAD-free survival adjudicated by a committee using ISHLT standard definitions. Measure: Serial post-transplant plasma samples (n=2152) were assayed for %ddcfDNA by shotgun sequencing. Analyses : Baseline characteristics, post-transplant %ddcfDNA trends, tacrolimus trough levels and CLAD-free survival were compared between AA and W. Results LTx recipients were 79% W and 14 % AA. Donor-recipient race mismatch was more commonly observed for AA than for W (75.0% vs. 27.3%, p Conclusion AA LTx show higher allograft injury and poorer CLAD-free survival than W LTx despite equivalent tacrolimus blood levels. Studies to understand the mechanisms of allograft injury and poor outcomes in AA are warranted across all solid organ transplants. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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