Substitution électrophile aromatique. VII. Étude de l'étape déterminants de l'iododéstannylation par effet de solvant

Autor:	Ouri Buchman, Mireille Grosjean, Jacques Nasielski, Étienne Hannecart
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Reaction rate constant chemistry Nucleophile Reagent Organic chemistry chemistry.chemical_element General Chemistry Methanol Electrophilic aromatic substitution Tin Iodine Medicinal chemistry
Zdroj:	Bulletin des Sociétés Chimiques Belges. 77:15-19
ISSN:	0037-9646
DOI:	10.1002/bscb.19680770102
Popis:	The reaction of phenyltrimethyltin with iodine is faster than that of phenyltriisopropyltin, but the ratio of the second order rate constants for both compounds is however the same in methanol and in isopropanol. Since isopropanol is less nucleophilic towards tin than methanol, it is concluded that the rate-determining step in this electrophilic aromatic substitution is the attack by the reagent, and that the breaking of the carbon-tin bond is a fast, kinetically non significant step.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::43897478f307c9269b362557338ed5c4 https://doi.org/10.1002/bscb.19680770102 Zobrazit plný text záznamu