Effect of Coenzyme Q10 on Myopathic Symptoms in Patients Treated With Statins
| Autor: | Giuseppe Caso, William Lawson, Margaret A. McNurlan, Patricia J. Kelly |
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| Rok vydání: | 2007 |
| Předmět: |
Coenzyme Q10
Vitamin medicine.medical_specialty Statin biology business.industry Cholesterol medicine.drug_class Coenzyme A Vitamin E medicine.medical_treatment Gastroenterology chemistry.chemical_compound chemistry Internal medicine medicine Physical therapy Cardiology biology.protein Creatine kinase medicine.symptom Cardiology and Cardiovascular Medicine business Myopathy |
| Zdroj: | The American Journal of Cardiology. 99:1409-1412 |
| ISSN: | 0002-9149 |
| Popis: | Treatment of hypercholesterolemia with statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) is effective in the primary and secondary prevention of cardiovascular disease. However, statin use is often associated with a variety of muscle-related symptoms or myopathies. Myopathy may be related in part to statin inhibition of the endogenous synthesis of coenzyme Q10, an essential cofactor for mitochondrial energy production. The aim of this study is to determine whether coenzyme Q10 supplementation would reduce the degree of muscle pain associated with statin treatment. Patients with myopathic symptoms were randomly assigned in a double-blinded protocol to treatment with coenzyme Q10 (100 mg/day, n = 18) or vitamin E (400 IU/day, n = 14) for 30 days. Muscle pain and pain interference with daily activities were assessed before and after treatment. After a 30-day intervention, pain severity decreased by 40% (p |
| Databáze: | OpenAIRE |
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