Scaling up Metal Scavenging Operations for Pharmaceutical Pilot Plant Manufactures

Autor:	Paul Sadler, Robin D. Wilkes, Gloriana Reginato
Rok vydání:	2011
Předmět:	business.industry Chemistry Organic Chemistry chemistry.chemical_element Nanotechnology Precious metal Scavenger (chemistry) Rhodium Metal Cartridge Pilot plant Filter (video) visual_art visual_art.visual_art_medium Physical and Theoretical Chemistry Process engineering business Palladium
Zdroj:	Organic Process Research & Development. 15:1396-1405
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op200127y
Popis:	Functionalised silicas, used for selectively removing metal impurities in process streams, are packed in cartridges and inserted into multicartridge filters. The scavenging step that follows a catalytic reaction involves the single pass of the process stream through the multicartridge filter setup at a predetermined linear velocity and temperature. Efficiency in metal reduction as high as 98% has been so far achieved at tens of kilograms scale. Furthermore, the precious metal anchored onto the scavenger’s functionalities can be recovered and refined. Our chronological development of a versatile, general, and easily scalable format for metal scavenging at process scales is described, illustrated by application in real time to a range of projects passing through our Pharmaceutical Pilot Plant, employing a variety of metals (palladium, rhodium, iridium). Benefits of the cartridge format in terms of economics and environmental impact are also initially assessed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::43533ec335c3a79f0408e9d462a8cdd4 https://doi.org/10.1021/op200127y Zobrazit plný text záznamu