Myxoid variant of primary cutaneous anaplastic large cell lymphoma: First 2 cases
| Autor: | David S. Cassarino, Angel Fernandez-Flores, Ariana Eginli |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Histology CD30 medicine.diagnostic_test business.industry Primary cutaneous anaplastic large cell lymphoma Dermatology medicine.disease Pathology and Forensic Medicine Lymphoma 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Dermis Positron emission tomography hemic and lymphatic diseases 030220 oncology & carcinogenesis Biopsy medicine Bone marrow business Anaplastic large-cell lymphoma |
| Zdroj: | Journal of Cutaneous Pathology. 44:772-775 |
| ISSN: | 0303-6987 |
| DOI: | 10.1111/cup.12983 |
| Popis: | Anaplastic large cell lymphoma (ALCL) is a CD30+ T-cell non-Hodgkin lymphoma with two main clinical presentations: primary cutaneous (pcALCL) and systemic (sALCL). While rare cases of myxoid sALCL have been reported, there are no previous cases of myxoid pcALCL reported. We present two unusual cases of pcALCL showing prominent collections of dermal mucin closely intermingling with the anaplastic lymphocytes. Patient 1 was a 30-year-old woman who presented with ulcerated nodules on her neck, abdomen, chest, and shoulders. A systemic lymphoma was excluded by physical examination, positron emission tomography and computed tomography (PET-CT) scan, as well as by bone marrow biopsy and flow cytometry studies. The patient was closely followed up for 10 months without evidence of systemic involvement. The biopsy showed diffuse infiltration of the dermis by a CD2+, CD30+, ALK-negative ALCL. Patient 2 was a 55-year-old woman who presented with a single nodule on her right arm. A systemic lymphoma was excluded by physical examination as well as by a PET-CT scan. The biopsy showed diffuse and dense lymphoid infiltration of the whole biopsy by a CD3+, CD4+, CD30+, ALK-negative ALCL. The atypical lymphocytes were intermingled with large amounts of dermal stromal mucin. |
| Databáze: | OpenAIRE |
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