A novel synthesis of EGFR-tyrosine-kinase inhibitors with 4-(indol-3-yl)quinazoline structure

Autor:	Werner Löwe, Anja Lüth
Rok vydání:	2008
Předmět:	Indole test chemistry.chemical_compound chemistry Epidermal growth factor Cell culture Kinase Cell surface receptor Stereochemistry Organic Chemistry Quinazoline Cytotoxic T cell Receptor
Zdroj:	Journal of Heterocyclic Chemistry. 45:703-708
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570450311
Popis:	The epidermal growth factor (EGF) family of membrane receptors has been identified as a key element in the complex signaling network that is utilized by various classes of cell-surface receptors. A new synthetic pathway of 4-(indol-3-yl)quinazolines 15 and 16 is described using cross coupling reactions with quinazoline- and indole moieties. The synthesized compound 15 is a new dual and high potent EGFR- and HER-2-tyrosine kinase inhibitor with excellent cytotoxic properties at different cell lines. Furthermore this substance class shows remarkably strong fluorescence.
Databáze:	OpenAIRE
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