Hörverlust durch Hochdosis-Carboplatintherapie
| Autor: | O. Kloke, J. Lautermann, W.-J. F. ten Cate, M. Adamczyk |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Oncology
medicine.medical_specialty endocrine system diseases Hearing loss medicine.medical_treatment Salvage therapy urologic and male genital diseases chemistry.chemical_compound Ototoxicity Internal medicine otorhinolaryngologic diseases medicine neoplasms Testicular cancer Cisplatin Chemotherapy medicine.diagnostic_test business.industry medicine.disease female genital diseases and pregnancy complications Carboplatin Surgery Otorhinolaryngology chemistry Audiometry medicine.symptom business medicine.drug |
| Zdroj: | Laryngo-Rhino-Otologie. 77:82-84 |
| ISSN: | 1438-8685 0935-8943 |
| DOI: | 10.1055/s-2007-996937 |
| Popis: | Background Carboplatin is regarded as a non-ototoxic or low-grade ototoxic chemotherapeutic agent. Method We report on three patients with a recurrence of testicular cancer after cisplatin chemotherapy who suffered hearing loss after subsequent high-dose carboplatin therapy. Results Audiometry demonstrated carboplatin-induced hearing loss primarily in the mid-range and high frequencies up to 45 dB at 3 kHz and up to 55 dB at 8 kHz. In two of three patients, transitory-evoked otoacoustic emissions were absent after carboplatin therapy. Conclusion Following first-line cisplatin chemotherapy, salvage treatment with high-dose carboplatin can generate hearing loss in the middle and high frequencies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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