The isolation and structure determination of cryptomisrine, a novel indolo[3,2-b]quinoline dimeric alkaloid fromcryptolepis sanguinolenta

Autor: Ronald C. Crouch, Gary E. Martin, Charles H. Phoebe, Doug Minick, Paul L. Schiff, Maged H. M. Sharaf, Robert L. Johnson, Albert N. Tackie, C. Webster Andrews
Rok vydání: 1996
Předmět:
Zdroj: Journal of Heterocyclic Chemistry. 33:789-797
ISSN: 1943-5193
0022-152X
DOI: 10.1002/jhet.5570330343
Popis: The isolation and structure determination of cryptomisrine, a novel indolo[3,2-b]quinoline dimeric alkaloid obtained from extracts of the roots of the Ghanaian medicinal plant Cryptolepis sanguinolenta is reported. The structure determination was made via a consideration of the spectral data, including uv, ir, nmr, and mass spectra. In particular, one-dimensional proton/carbon nmr, one-dimensional nOe difference nmr, and a series of homonuclear (COSY) and inverse-detected heteronuclear two-dimensional (HMQC, HMBC) experiments were utilized, as well as high resolution FABMS. Cryptomisrine is most unusual in that its two monomeric parts apparently exist in such a C2 symmetric environment that only one set of proton and carbon nmr resonances are observed. Cryptomisrine is the first example of a dimeric indolo-[3,2-b]quinoline alkaloid to have been isolated from nature.
Databáze: OpenAIRE
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