Abstract 15563: Neurovascular Control and Spontaneous Baroreflex Sensitivity in Heart Failure Patients with Preserved Ejection Fraction
| Autor: | Ana Luiza C Sayegh, Marcelo R dos Santos, Francis R de Souza, Vera Maria C Salemi, Carlos Augusto P Oliveira, Felipe X Fonseca, Sara Rodrigues, Ivani C Trombetta, Edgar Toschi-Dias, Carlos Eduardo Negrão, Maria-Janieire N Alves, Charles Mady |
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| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Circulation. 130 |
| ISSN: | 1524-4539 0009-7322 |
| Popis: | Introduction: Muscle sympathetic nerve activity (MSNA) and forearm blood flow (FBF) are markers of mortality in Systolic Heart Failure (S-HF). Endomyocardial Fibrosis (EMF) is a Heart Failure (HF) with Preserved Ejection Fraction (PEF-HF). Although mortality in PEF-HF can be similar to S-HF, it is still unknown if neurovascular control is impaired in PEF-HF. Hypothesis: Our hypothesis is that even though PEF-HF show normal ejection fraction, they have the same autonomic dysfunction as S-HF. The aim was to evaluate MSNA, FBF and spontaneous baroreflex sensitivity (SBS) in PEF-HF compared to S-HF and healthy subjects (HS). Methods: Nineteen females HF, NYHA class II and III, were divided in two groups: PEF-HF (n=10) and S-HF (n=9), and were compared to HS (n=7). Left Ventricular Ejection Fraction (LVEF), by echocardiography (Simpson); MSNA, by microneurography; FBF, by venous occlusion plethysmography; mean blood pressure (MBP) and heart rate (HR) by Finometer; SBS, by sequence method, were measured. Significance was considered p Results: Age was not different between PEF-HF, S-HF and HS (57±2 vs. 55±2 vs. 52±1 years; p Conclusion: These results point out that even though PEF-HF have a normal ejection fraction, they showed neurovascular control as impaired as S-HF with lower SBS compared to HS. |
| Databáze: | OpenAIRE |
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