ChemInform Abstract: Rhodium-Catalyzed Reduction of Esters to Alcohols Using Diphenylsilane

Autor:	Mami Nobutomo, Keisuke Kusui, Isao Furukawa, Tetsuo Ohta, Tsugumi Michibata, Masahiro Kamiya
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Ethyl phenylacetate Ethyl decanoate Chemistry Organic chemistry chemistry.chemical_element General Medicine Catalysis Rhodium
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199948070
Popis:	Carboxylic esters were reduced to alcohols by diphenylsilane catalyzed by a Rh complex at room temperature. For example, ethyl decanoate and ethyl phenylacetate were converted to decanol and 2-phenylethanol by [ RhCl(cod) ] 2 4PPh 3 for 72 hours in 98 and 92% yields, respectively. Wilkinson's catalyst is also usable, and the reduction of ethyl decanoate finished in 6 hours at room temperature. The bromo-substitutent on ethyl 7-bromoheptanoate remained intact through this reduction.
Databáze:	OpenAIRE
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