Autor:	D. B. Kazanskii, T. V. Anfalova, L. M. Khromykh
Rok vydání:	2003
Předmět:	Lysis Lymphokine-activated killer cell Effector Chemistry Apoptosis Cell growth Immunology Cytotoxic T cell Inhibitory effect In vitro Developmental Biology Cell biology
Zdroj:	Russian Journal of Developmental Biology. 34:223-231
ISSN:	1062-3604
DOI:	10.1023/a:1024944532328
Popis:	The data presented demonstrate the capacity of allospecific cytotoxic lymphocytes to fulfill noncytolytic regulatory functions. Cytotoxic lymphocytes suppress cell proliferation induced during development of a response in reactions of a mixed culture of lymphocytes and blast transformation irrespective of haplotypes of the cells involved in these reactions. At the same time, cytotoxic lymphocytes do not practically affect spontaneous proliferation of T-cells. The inhibitory effect of cytotoxic lymphocytes is expressed only upon direct contact with activated T-lymphocytes and is not relate to their apoptosis and death. The results obtained suggest polyfunctionality of allospecific cytotoxic lymphocytes expressed in the capacity of these lymphocytes to fulfill both effector (target lysis) and regulatory functions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::40db18ca0ba504fe67c77662d61b5318 https://doi.org/10.1023/a:1024944532328 Zobrazit plný text záznamu Full text from SpringerLink