In vitro Anti-Influenza Virus Activity of Agaricus brasiliensis KA21
| Autor: | Nao Eguchi, Kenji Oonaka, Kan Fujino, Khompakorn Thanasut, Motoko Taharaguchi, Akitomo Motoi, Satoshi Taharaguchi, Masuro Motoi |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Strain (chemistry) biology Chemistry viruses H1N1 influenza Public Health Environmental and Occupational Health virus diseases biology.organism_classification Applied Microbiology and Biotechnology In vitro Virus Microbiology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Agaricus 030212 general & internal medicine Agaricus brasiliensis IC50 Inhibitory effect |
| Zdroj: | Biocontrol Science. 22:171-174 |
| ISSN: | 1884-0205 1342-4815 |
| DOI: | 10.4265/bio.22.171 |
| Popis: | Agaricus is known to have immunostimulatory and anti-tumor effects. However, the antiviral effects of Agaricus have not yet been examined. In the present study, the antiviral effects of an extract of Agaricus brasiliensis KA21 (AE) on the H1N1 influenza virus (PR8 strain) were investigated. The anti-influenza virus effects of AE were examined by using the plaque formation inhibition test. AE inhibited the plaque formation of PR8 in a dose-dependent manner: 98 and 50% (IC50) inhibition at 2.5 and 0.99 mg/mL, respectively. To elucidate the mechanisms of AE, the direct actions and adsorption and invasion inhibition of AE were examined, and were found to have no inhibitory effect on PR8 infection. Thus, in vitro antiviral effects may somehow inhibit PR8 after the viral invasion of cells. These results demonstrated that it is expected that AE can effectively prevent the spread of the influenza virus. |
| Databáze: | OpenAIRE |
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