| Autor: |
Alex Simon, Connor Edsall, Eli Vlaisavljevich |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
The Journal of the Acoustical Society of America. 152:A247-A247 |
| ISSN: |
0001-4966 |
| DOI: |
10.1121/10.0016161 |
| Popis: |
Histotripsy is a cavitation-based focused ultrasound ablation method in development for multiple clinical applications. This work investigates the effects of pulse repetition frequency (PRF) on histotripsy bubble cloud characteristics and ablative capabilities for single cycle histotripsy. Bubble clouds produced by a 500 kHz histotripsy system at PRF’s from 0.1 to 1000 Hz were visualized using high speed imaging in 1% agarose phantoms. Cloud images were analyzed to determine bubble cloud density (bubbles/mm2) and pulse-to-pulse bubble correlation. Ablation was assessed through lesion analysis in red blood cell (RBC) phantoms. Results showed cavitation clouds generated at low PRF were characterized by consistently dense bubble clouds (49.6 ± 7.7 bubbles/mm2, 1 Hz) that closely matched regions above the histotripsy intrinsic threshold. Bubble clouds formed at high PRF had significantly lower cloud density (20.0 ± 8.3 bubbles/mm2, 1000 Hz). In addition, bubbles in higher PRF clouds had significantly increased pulse-to-pulse correlation, characteristic of what has been reported as the cavitation memory effect. Results from RBC ablation showed that higher PRF generated lesions had lower adherence to the focal region and less repeatability compared to low PRF ablations. This study demonstrates essential differences in bubble cloud characteristics that will help guide future histotripsy pulsing strategies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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