Comparing monovalent and combination hepatitis B vaccine outcomes in children delivered by mothers with chronic hepatitis B
| Autor: | Le Y Lee, Si M Chan, Christina Ong, Kong B Phua, Marion M. Aw, Guan H Lee, Koh Cheng Thoon, Franco Wong, Sharon Saw |
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| Rok vydání: | 2018 |
| Předmět: |
Hepatitis B virus
Hepatitis Pediatrics medicine.medical_specialty Hepatitis B vaccine business.industry Transmission (medicine) Hepatitis C medicine.disease_cause medicine.disease Vaccination 03 medical and health sciences Regimen 0302 clinical medicine 030225 pediatrics Pediatrics Perinatology and Child Health Cohort medicine 030212 general & internal medicine business |
| Zdroj: | Journal of Paediatrics and Child Health. 55:327-332 |
| ISSN: | 1034-4810 |
| DOI: | 10.1111/jpc.14194 |
| Popis: | Aim We compared the vaccine effectiveness of monovalent and combination hepatitis B vaccine regimens in infants born to chronic hepatitis B carrier mothers. Methods An observational cohort of neonates was recruited over 78 months from two public hospital maternity units in Singapore. We enrolled term infants, born to chronic hepatitis B surface antigen-positive mothers regardless of their hepatitis Be antigen status, who completed the hepatitis B virus (HBV) vaccination programme in Singapore. Infants born to mothers on antiviral therapy, or with concurrent hepatitis C or human immunodeficiency virus infection were excluded. All infants received hepatitis B immunoglobulin at birth. One group received three doses of monovalent hepatitis B vaccine (0, 1, 6 months) (regimen A). The other group received two doses of monovalent vaccine, followed by one dose combination vaccine DTaP-IPV-Hib-HBV (0, 1, 6 months) (regimen B). Vaccine effectiveness was determined by immunoprophylaxis failure leading to HBV vertical transmission. Immunogenicity was assessed by hepatitis B surface antibody (anti-HBs) levels at 9 months of age. Results Total of 177 term neonates received regimen A and 115 received regimen B. Immunoprophylaxis failure rate was low, 2.3 and 2.6% (P = 1.00) in regimen A and B, respectively. Mean anti-HBs titres were similar at 643 ± 374 and 561 ± 396 IU/L (P = 0.08) for regimen A and B, respectively. Conclusion Hepatitis B vaccine regimens using monovalent or combination vaccine for the third dose showed similarly high vaccine effectiveness and low immunoprophylaxis failure rate in term infants born to chronic hepatitis B carrier mothers. |
| Databáze: | OpenAIRE |
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