On the para-selective chlorination of ortho-cresol

Autor:	Emmanuelle A. Bugnet, Robert Greatrex, Adrian R. Brough, Terence P. Kee
Rok vydání:	2002
Předmět:	Steric effects chemistry.chemical_compound chemistry Organic Chemistry Drug Discovery Electrophile polycyclic compounds medicine Organic chemistry Cresol Biochemistry medicine.drug Merrifield resin
Zdroj:	Tetrahedron. 58:8059-8065
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(02)00996-1
Popis:	Merrifield-bound o-cresol undergoes electrophilic aromatic chlorination using SO2Cl2 leading to para/ortho ratios in excess of 50, the highest such ratio reported for this chlorinating agent. Model studies suggest that this significant para/ortho ratio results not just from steric effects but that considerable electronic influence can be detected.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::40272f7887ec1ed6aade003cf9c2b7da https://doi.org/10.1016/s0040-4020(02)00996-1 Zobrazit plný text záznamu Full Text from ScienceDirect