Multi-faceted regulation of ?-glutamylcysteine synthetase
| Autor: | Michael L. Freeman, Konjeti R. Sekhar, Syrus R. Soltaninassab, Michael J. Meredith |
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| Rok vydání: | 2000 |
| Předmět: |
chemistry.chemical_classification
Antioxidant Regulatory enzymes Physiology medicine.medical_treatment Clinical Biochemistry Disulfide bond Cell Biology Glutathione Biology chemistry.chemical_compound chemistry Biochemistry Gamma-Glutamylcysteine synthetase medicine Metalloprotein Transcriptional regulation |
| Zdroj: | Journal of Cellular Physiology. 182:163-170 |
| ISSN: | 1097-4652 0021-9541 |
| DOI: | 10.1002/(sici)1097-4652(200002)182:2<163::aid-jcp4>3.0.co;2-1 |
| Popis: | Glutathione is an important antioxidant that is involved in numerous cellular activities. gamma-Glutamylcysteine synthetase (gammaGCS) is a key regulatory enzyme in the synthesis of glutathione. It is a heterodimeric zinc metalloprotein that belongs to a unique class of proteins that gain activity due to formation of a reversible disulfide bond. The two subunits of gammaGCS exhibit differential and coordinate transcription regulation. In addition, the subunits are regulated at the posttranscriptional and posttranslational levels. These various levels of regulation allow numerous stimuli to induce or inhibit activity. |
| Databáze: | OpenAIRE |
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