Reusable silica-bonded S-sulfonic acid catalyst for three-component synthesis of 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes and 2-amino-4H-pyrans in aqueous ethanol

Autor:	H. Ramadoss, S.P.N. Sudhan, V. Saleem Malik, K. Logaiya, S. Sheik Mansoor, K. Aswin
Rok vydání:	2013
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Yield (chemistry) Ethyl acetoacetate Dimedone Organic chemistry General Chemistry Aqueous ethanol Sulfonic acid Malononitrile Catalysis
Zdroj:	Research on Chemical Intermediates. 40:2583-2598
ISSN:	1568-5675 0922-6168
DOI:	10.1007/s11164-013-1111-6
Popis:	Silica-bonded S-sulfonic acid (SBSSA)-catalyzed, facile, one-pot, three-component coupling of 5,5-dimethyl-1,3-cyclohexanedione (dimedone) or 5,5-dimethyl-1,3-cyclohexanedione, aromatic aldehydes, and malononitrile at reflux temperature is described for preparation of 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene derivatives. 2-Amino-3-cyano-6-methyl-4-phenyl-4H-pyran-5-ethylcarboxylate derivatives can also be prepared in good yield under the same experimental conditions by use of ethyl acetoacetate, aldehydes, and malononitrile. The catalyst, silica-bonded S-sulfonic acid, was reused and recycled without any loss of activity or product yield.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3fcd6c055efd6bf6f3b8d1112b82e851 https://doi.org/10.1007/s11164-013-1111-6 Zobrazit plný text záznamu Full text from SpringerLink