Mouse retinal adaptive response to proton irradiation: Correlation with DNA repair and photoreceptor cell death
| Autor: | V. A. Poplinskaya, E. I. Nekrasova, M. A. Ostrovsky, V. A. Tronov, Yu. V. Vinogradova |
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| Rok vydání: | 2015 |
| Předmět: |
Retinal degeneration
Physics Nuclear and High Energy Physics Retina Radiation genetic structures business.industry DNA repair Retinal medicine.disease eye diseases Atomic and Molecular Physics and Optics Photoreceptor cell Ionizing radiation Cell biology chemistry.chemical_compound Optics medicine.anatomical_structure chemistry medicine Cytotoxic T cell Radiology Nuclear Medicine and imaging sense organs business Cytotoxicity |
| Zdroj: | Physics of Particles and Nuclei Letters. 12:173-183 |
| ISSN: | 1531-8567 1547-4771 |
| DOI: | 10.1134/s1547477115010227 |
| Popis: | Emerging body of data indicate protecting effect of low level of stress (preconditioning) on retina. Our previous study revealed non-linear dose-response relationship for cytotoxicity of both ionizing radiation and N-methyl-N-nitrosourea (MNU) on mouse retina. Moreover, non cytotoxic dose of MNU increased tolerance of retina to following challenge dose of MNU. This result displays protection of retina through mechanism of recovery. In present study we used the mouse model for MNU-induced retinal degeneration to evaluate adaptive response of retina to proton irradiation and implication in it of glial Muller cells. The data showed that the recovery of retina after genotoxic agents has been associated with increased efficacy of DNA damage repair and lowered death of retinal photoreceptor cells. |
| Databáze: | OpenAIRE |
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