Molecular analysis of isoniazid-resistant Mycobacterium tuberculosis isolates in Uruguay [Short communication]
| Autor: | Carlos Robello, C. Rivas, Cecilia Coitinho, Gonzalo Greif, J. van Ingen |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pulmonary and Respiratory Medicine
Tuberculosis Sequence analysis Incidence (epidemiology) Isoniazid respiratory system biochemical phenomena metabolism and nutrition Biology bacterial infections and mycoses medicine.disease biology.organism_classification respiratory tract diseases Microbiology Molecular analysis Mycobacterium tuberculosis Infectious Diseases Genotype medicine heterocyclic compounds Genotyping medicine.drug |
| Zdroj: | The International Journal of Tuberculosis and Lung Disease. 16:947-949 |
| ISSN: | 1027-3719 |
| DOI: | 10.5588/ijtld.11.0559 |
| Popis: | The incidence of tuberculosis (TB) is increasing in high-risk populations in Uruguay, possibly owing to emerging resistance. Mycobacterial interspersed repetitive units (MIRU) genotyping and katG sequence analysis of isoniazid (INH) resistance-associated mutations were performed in 45 INH-resistant Mycobacterium tuberculosis isolates in Uruguayan patients. The genotype distribution among INH-resistant isolates shares features of that of neighbouring countries, with a predominance of Latin American and Mediterranean, T and Haarlem genotypes, although the S genotype was particularly frequent among our isolates. Forty-four per cent of INH-resistant strains harboured the S315T mutation in katG; we found novel katG mutations (W321X, G269T, P232R and G221Wfs1) that could explain INH resistance. |
| Databáze: | OpenAIRE |
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