Cycloaddition in synthesis of sulfonamide derivatives. III. Convenient synthesis of 3-alkylthio-4H-1,2,4-benzothiadiazine 1,1-dioxides

Autor:	Tsuneo Iwakawa, Yoshio Hayase, Hiroto Tamura
Rok vydání:	1990
Předmět:	Chlorosulfonyl isocyanate chemistry.chemical_classification Bicyclic molecule General Chemistry General Medicine Cycloaddition Sulfonamide chemistry.chemical_compound chemistry Benzothiadiazine Drug Discovery Organic chemistry Dithiocarbamate Friedel–Crafts reaction Carbonyl sulfide
Zdroj:	Chemical and Pharmaceutical Bulletin. 38:1075-1076
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.38.1075
Popis:	Synthesis of 3-alkylthio-4-methyl-4H-1, 2, 4-benzothiadiazine 1, 1-dioxides was conveniently achieved by [2+2] cycloaddition reaction of S-alkyl N-methyl-N-phenyldithiocarbamates with chlorosulfonyl isocyanate with subsequent loss of carbonyl sulfide, followed by cyclization of the resulting chlorosulfonyl isothioureas under Friedel-Crafts conditions.
Databáze:	OpenAIRE
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