| Popis: |
The formulation of only moderately water-soluble pharmaceuticals can benefit from the incorporation of nanoparticles, which increases the drugs’ bioavailability. The primary objective of this work was to create and evaluate fluvastatin-loaded nanoparticles using the precipitation process to improve their solubility and bioavailability. Precipitation was used to prepare fluvastatin nanoparticles, which are classified as a BCS class II drug. These particles were then characterized using techniques such as Fourier transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy, zeta potential, and in-vitro drug release studies. There was no evidence of contact between the drug and the polymers based on the differential scanning calorimetry results, powder X-ray diffractometry, and Fourier transforms infrared spectroscopy. Images obtained by scanning electron microscopy revealed that the nanoparticles had a spherical form. The fact that the water solubility of drug-loaded nanoparticles was increased in comparison to the pure drug and that they displayed an improved dissolution profile was evidence that nanoprecipitation was a straightforward and accurate process. Both this technology on a laboratory scale and this strategy could be used to improve the solubility and bioavailability of BCS class II medications. |
