Decreased lysyl oxidase activity in the aneurysm-prone, mottled mouse

Autor:	David W. Rowe, George R. Martin, D Grahn, Ermona B. McGoodwin
Rok vydání:	1977
Předmět:	medicine.medical_specialty integumentary system biology Connective tissue Lysyl oxidase Cell Biology Metabolism medicine.disease Biochemistry Aneurysm Endocrinology medicine.anatomical_structure Lysyl oxidase activity Internal medicine medicine biology.protein Allele Molecular Biology Elastin
Zdroj:	Journal of Biological Chemistry. 252:939-942
ISSN:	0021-9258
DOI:	10.1016/s0021-9258(19)75188-6
Popis:	Inbred mice bearing certain alleles at the Mottled locus have defects in connective tissue which result in weakness of skin and of blood vessels. Previous studies have established that cross-links in collagen and elastin are decreased in these animals due to impaired formation of lysine-derived aldehydes. Lysyl oxidase activity in extracts of skin is markedly lower in those prepared from affected animals than control mice. An inhibitor of lysyl oxidase is present in equal amounts in affected and control skins and does not account for diminished activity found in affected animals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3eda2bae7adef62d1aac12ae50335239 https://doi.org/10.1016/s0021-9258(19)75188-6 Zobrazit plný text záznamu