Preparation of absorbable surgical suture: Novel approach in biomedical application
| Autor: | Tamilselvi Alagumuthu, Gunadharini Nandhagobal, Sastry Thotapalli Parvathaleswara, Senthil Rethinam, Berly Robert |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Thermogravimetric analysis Materials science Scanning electron microscope Plasticizer Pharmaceutical Science 02 engineering and technology 021001 nanoscience & nanotechnology 03 medical and health sciences chemistry.chemical_compound Surgical suture 030104 developmental biology Suture (anatomy) chemistry Ultimate tensile strength Fourier transform infrared spectroscopy 0210 nano-technology Ethylene glycol Biomedical engineering |
| Zdroj: | Journal of Drug Delivery Science and Technology. 47:454-460 |
| ISSN: | 1773-2247 |
| Popis: | In the present investigation suture material was prepared using collagen, prepared from tannery solid waste and impregnated with a plasticizer, which can be used for external surgical applications. Collagen was blended with ethylene glycol and lyophilized to get a semisolid collagen paste, which was used for the preparation of the absorbable suture (AS). The prepared AS was characterized using Fourier transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA), and scanning electron microscopy (SEM) techniques. In addition, in vitro and in vivo studies were also carried out. The developed novel ASs revealed their biodegradable properties that make them suitable for biomedical engineering applications. The unique feature of the AS is that it exhibits tensile strength as high as 43.16 ± 1.03 MPa and can be stored for a period of six months. The study indicate that the developed ASs have potential wound healing as well as external surgical application. It also provides an opportunity for utilization of solid leather wastes generated by tanneries to make value added medical products for biomedical applications. |
| Databáze: | OpenAIRE |
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