| Autor: |
B.S. Bunney, L.R. Skirboll |
| Rok vydání: |
1979 |
| Předmět: |
|
| DOI: |
10.1016/b978-1-4832-8363-0.50193-2 |
| Popis: |
The effects of chronic haloperidol (HAL) treatment on the spontaneous activity of rat caudate neurons were determined using extracellular single unit recording techniques. Two types of spontaneous potentials were observed: monophasic and biphasic. Chronic HAL treatment increased the number of active monophasic potentials while it decreased the number of active biphasic units. Monophasic potentials also showed a supersensitivity to dopamine (DA). It is hypothesized that these time-dependent changes in caudate cell activity may correlate with the development of clinical neurologic side-effects induced by neuroleptic treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
