The Association of Visceral Adiposity Index with Insulin Resistance in Adults with Prediabetes

Autor:	Muhammad Abul Hasanat, Tohfa-E-Ayub, Md. Shahed-Morshed, Naureen Mahbub, Sultana Parveen, Tahniyah Haq, Md. Fariduddin
Rok vydání:	2021
Předmět:	medicine.medical_specialty Waist Triglyceride business.industry Cholesterol Insulin medicine.medical_treatment medicine.disease chemistry.chemical_compound Endocrinology Insulin resistance chemistry Internal medicine Homeostatic model assessment Medicine Prediabetes business Body mass index
Zdroj:	Open Journal of Endocrine and Metabolic Diseases. 11:12-23
ISSN:	2165-7432 2165-7424
DOI:	10.4236/ojemd.2021.111002
Popis:	Visceral adiposity mediates insulin resistance, but their association among adults with prediabetes is scarce in the literature. This study is aimed to determine the association of visceral adiposity index (VAI) with insulin resistance in adults with prediabetes. This cross-sectional study was done among 117 adults with newly detected prediabetes [m/f; 23/94; mean ± SD: Age 36.30 ± 9.99 years, BMI 28.89 ± 4.35 kg/m2] based on American Diabetes Association 2018 criteria and 141 matched healthy controls [m/f: 28/113; mean ± SD: 35.30 ± 6.88 years, BMI 25.03 ± 4.58]. Waist circumference, body mass index, fasting triglyceride, HDL cholesterol, fasting blood glucose and insulin were measured in each group to calculate VAI and homeostatic model assessment of insulin resistance (HOMA-IR). People with prediabetes had significantly higher median value of VAI {3.08 (2.26) vs. 1.86 (2.31); p 1) (98.3% vs. 85.8%; p < 0.001) than the control population. HOMA-IR level was significantly higher in prediabetes with high VAI (cut-off of 2.64) than control with normal VAI [2.78 (2.22, 4.15) vs. 2.20 (1.53, 3.36); p = 0.002]. VAI was positively correlated with HOMA-IR in females with prediabetes (r = 0.299, p = 0.003). VAI had predictive association with prediabetes [OR (95% CI: 9.504 (2.173, 41.576); p = 0.03] and high insulin resistance (HOMA-IR ≥ 2.6) in females with prediabetes [OR (95% CI) = 3.50 (1.476, 8.297); p = 0.004] only. It could satisfactorily discriminate prediabetes in both sexes (male: AUC = 0.767, p = 0.001; female: AUC = 0.641, p < 0.001) and high insulin resistance in females with prediabetes (AUC = 0.641; p = 0.019) only. So, VAI was associated with prediabetes and insulin resistance only in females with prediabetes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3e01aa9d5eea08b99d70dc16e1d03147 https://doi.org/10.4236/ojemd.2021.111002 Zobrazit plný text záznamu