Stability of an Aqueous Extract of Larrea divaricata Cav. during a Simulated Digestion Process
| Autor: | Maria del Rosario Alonso, Renzo F. Martino, Claudia Anesini, Ignacio Nahuel Peralta, Demian Monti |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pharmacology 030109 nutrition & dietetics Antioxidant Chromatography biology Traditional medicine Chemistry medicine.medical_treatment food and beverages biology.organism_classification Antimicrobial Bioavailability Nordihydroguaiaretic acid 03 medical and health sciences Phytomedicine chemistry.chemical_compound 0302 clinical medicine Polyphenol Zygophyllaceae 030220 oncology & carcinogenesis medicine Larrea divaricata |
| Zdroj: | Phytotherapy Research. 31:1708-1714 |
| ISSN: | 0951-418X |
| DOI: | 10.1002/ptr.5897 |
| Popis: | Larrea divaricata Cav. (Zygophyllaceae) is a South American plant widely distributed in Argentina that is used in folk medicine to treat inflammatory diseases. The aqueous extract is known to have well-documented biological activities such as antitumour, immunomodulatory, antimicrobial, antiinflammatory and antioxidant. However, its stability in gastrointestinal fluids is unknown. The latter is an important factor to assure the bioavailability of plant extracts intended to be administered via the oral route. The aim of this work was to study the stability of a lyophilized aqueous extract of L. divaricata compressed as a pill. To this end, the main polyphenol compound found in the extract, that is, the nordihydroguaiaretic acid, the total polyphenols and flavonoids content and the antioxidant activity such as diphenylpicrylhydrazyl scavenger activity and reducing power were assayed after subjecting the extract to different incubation times in simulated digestive fluids. The HPLC and spectroscopic methods were employed. Although the levels of polyphenols and flavonoids decreased upon incubation in gastric and intestinal fluids, the extract maintained its antioxidant activity related to the presence of nordihydroguaiaretic acid. These results are promising and encourage the potential use of the extract by the oral route as a supplement or phytomedicine with antioxidant activity. Copyright © 2017 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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