Biotransformation enzyme activities and histopathology in rainbow trout, Salmo gairdneri, treated with cadmium
| Autor: | Per Runn, Åke Larsson, Carl Haux, L. Karlsson-Norrgren, Lars Förlin |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
inorganic chemicals
Kidney Cadmium urogenital system Stereochemistry Health Toxicology and Mutagenesis medicine.medical_treatment Intraperitoneal injection Glucuronidation chemistry.chemical_element Aquatic Science Pharmacology chemistry.chemical_compound medicine.anatomical_structure chemistry Biotransformation Toxicity medicine Rainbow trout Xenobiotic |
| Zdroj: | Aquatic Toxicology. 8:51-64 |
| ISSN: | 0166-445X |
| DOI: | 10.1016/0166-445x(86)90072-x |
| Popis: | The effects of intraperitoneal administration of cadmium and exposure to cadmium in the water on rainbow trout, Salmo gairdneri , were studied. The results of intraperitoneal injection of cadmium indicate that this metal has the potential to inhibit phase I and phase II xenobiotic biotransformation activities in the liver and kidney. The exposure to cadmium through water resulted in different responses in the liver and kidney. The marked inhibition of the glucuronidation reaction is of toxicological importance, since this may potentiate the toxic action of organic xenobiotics biotransformed through this pathway. This response in the kidney was accompanied by histopathological changes in the proximal renal tubules, which are probably associated with the plasma hypocalcaemic response observed in cadmium-poisoned fish. |
| Databáze: | OpenAIRE |
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