Dimeric dehydroaporphinoids with antiplasmodial properties from the liana of Artabotrys aurantiacus (Annonaceae)
| Autor: | Céline Mbazoa Djama, Dennis Eckelmann, Valery Wilfried Nguemdjo Chimeze, Sebastian Zühlke, Jean Wandji |
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| Rok vydání: | 2020 |
| Předmět: |
biology
Traditional medicine 010405 organic chemistry Chemistry Plasmodium falciparum Plant Science biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry Liana Annonaceae Artabotrys parasitic diseases Ic50 values Agronomy and Crop Science Two-dimensional nuclear magnetic resonance spectroscopy Biotechnology |
| Zdroj: | Phytochemistry Letters. 38:150-154 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2020.06.009 |
| Popis: | Artabotrys aurantiacus is a Cameroonian Medicinal plant used in traditional medicines to fight against Malaria. So far, there is no reported data on the chemical composition of this plant. From the CH2Cl2/MeOH (1:1) extract of the liana of A. aurantiacus, two new dimeric dehydroaporphine alkaloids, aurantiacine A (1) and B (2) were isolated along with nine known compounds. Their chemical structures were elucidated by means of HRESI-MSn and spectroscopic methods, including 1D and 2D NMR, and by comparison with data from the literature. The isolated compounds were evaluated for their anti-plasmodial activity in vitro against the erythrocytic stage of Plasmodium falciparum NF54. Compounds 1-4 displayed moderate anti-plasmodial properties with IC50 values of 0.6336, 0.1120, 0.2601 and 1.0159 μM respectively. |
| Databáze: | OpenAIRE |
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