A Catalyst-Free, Temperature-Driven One-Pot Synthesis of 1-Adamantylhydrazine Hydrochloride
| Autor: | James Hodgson, Stefan H. Bossmann, Anjana M. D. S. Delpe Acharige, Raul Neri |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
010405 organic chemistry 030306 microbiology Hydrochloride Organic Chemistry Extraction (chemistry) One-pot synthesis Organic layer 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound chemistry Yield (chemistry) Extraction methods |
| Zdroj: | Synthesis. 52:3374-3377 |
| ISSN: | 1437-210X 0039-7881 |
| DOI: | 10.1055/s-0040-1707353 |
| Popis: | 1-Adamantylhydrazine can be a versatile intermediate for many biologically active compounds as adamantyl possesses a wide spectrum of medicinal properties. Described here is a detailed one-pot synthesis of 1-adamantylhydrazine, carried out on a milligram to gram scale, that steadily delivers a highly stable product used to carry out the synthesis of 1-(adamantan-1-yl)-1H-pyrazol-3-amine for bacterial studies. The reaction employs inexpensive, catalyst free, readily available starting materials. In the synthesis of 1-(adamantan-1-yl)-1H-pyrazol-3-amine, the use of a continuous extraction method allows for complete extraction of the target product into the organic layer and increases the overall percentage yield. |
| Databáze: | OpenAIRE |
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