Growth Inhibitory Mechanism of Contact-independent Antifungal TM-I-3 Bacillus sporothermodurans Strain against Aspergillus fumigatus and Cladosporium cladosporioides
| Autor: | Shinji Mitsuiki, Shinji Urakawa, Hitomi Shimomoto, Chihiro Osaki, Hiroshi Sato, Sarasa Miyake |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
0303 health sciences biology Strain (chemistry) 030306 microbiology Chemistry Public Health Environmental and Occupational Health Bacillus Cladosporium cladosporioides biology.organism_classification 01 natural sciences Applied Microbiology and Biotechnology Aspergillus fumigatus Microbiology 03 medical and health sciences 010608 biotechnology Bacillus sporothermodurans Spore germination Mycelium Bacteria |
| Zdroj: | Biocontrol Science. 26:49-53 |
| ISSN: | 1884-0205 1342-4815 |
| DOI: | 10.4265/bio.26.49 |
| Popis: | We previously identified a new Bacillus sporothermodurans strain, TM-I-3, which produces volatile compounds that show potent inhibitory activity against certain types of fungi, including Aspergillus fumigatus and Cladosporium cladosporioides. Non-contact antifungals derived from this bacterium may provide multidirectional inhibition and may be useful in disease prevention. This study is aimed at identifying the stage of fungal growth that is inhibited by TM-I-3 to elucidate the mechanism of its contact-independent antifungal activity. We evaluated mycelial growth and the gross fungal colony areas after 7 days in each experimental group varying the time in the proximity of TM-I-3 for 24 hours each. The fungal growth inhibition assay showed that TM-I-3 inhibited spore germination: the lag phase in the sigmoid growth curve. The present study demonstrated that TM-I-3 might be an effective fungistatic agent against pathogenic and allergenic fungi. |
| Databáze: | OpenAIRE |
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