Synthesis and Biological Activity of Some New 5′-O-Acyl Tiazofurin Derivatives

Autor:	Ljubica Medić-Mijačević, Jelena Tasic, Mirjana Popsavin, Vjera Pejanovic, Mirjana Dacevic, Velimir Popsavin, Vesna Piperski, Esmir Gunic, Dragana Ugljesic-Kilibarda
Rok vydání:	2006
Předmět:	Chemistry Biological activity General Medicine Prodrug In vitro Cell membrane medicine.anatomical_structure Biochemistry Apoptosis Cell culture medicine Intracellular Tiazofurin medicine.drug
Zdroj:	ChemInform. 37
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200638183
Popis:	Three new 5'-O-acyl tiazofurin derivatives 2-4 were synthesized and evaluated for their antiproliferative activity against different tumour cell lines as well as for their ability to induce apoptosis in C6 cells in vitro. Apart of the antitumour assays, the cell membrane permeation of 2-4 and their intracellular metabolism in C6 cells in vitro was also studied in order to evaluate their potential as possible tiazofurin bioisosteres or prodrugs.
Databáze:	OpenAIRE
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