Increased physical activity decreases hepatic free fatty acid uptake: a study in human monozygotic twins
| Autor: | Tapio Viljanen, Tuula Janatuinen, Olli J. Heinonen, Juhani Knuuti, Jaakko Kaprio, Borra Ronald, Urho M. Kujala, Pirjo Nuutila, Tapani Rönnemaa, Merja Haaparanta, Jarna C. Hannukainen, Jukka Kapanen, Kari K. Kalliokoski, Riitta Parkkola |
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| Rok vydání: | 2006 |
| Předmět: |
2. Zero hunger
chemistry.chemical_classification medicine.medical_specialty Physiology Skeletal muscle Adipose tissue Fatty acid Monozygotic twin 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Biology medicine.disease Body fat percentage 03 medical and health sciences 0302 clinical medicine Endocrinology medicine.anatomical_structure Insulin resistance chemistry Internal medicine medicine Aerobic exercise Body mass index |
| Zdroj: | The Journal of Physiology. 578:347-358 |
| ISSN: | 0022-3751 |
| DOI: | 10.1113/jphysiol.2006.121368 |
| Popis: | Exercise is considered to be beneficial for free fatty acid (FFA) metabolism, although reports of the effects of increased physical activity on FFA uptake and oxidation in different tissues in vivo in humans have been inconsistent. To investigate the heredity-independent effects of physical activity and fitness on FFA uptake in skeletal muscle, the myocardium, and liver we used positron emission tomography (PET) in nine healthy young male monozygotic twin pairs discordant for physical activity and fitness. The cotwins with higher physical activity constituting the more active group had a similar body mass index but less body fat and 18 +/- 10% higher (P < 0.001) compared to the less active brothers with lower physical activity. Low-intensity knee-extension exercise increased skeletal muscle FFA and oxygen uptake six to 10 times compared to resting values but no differences were observed between the groups at rest or during exercise. At rest the more active group had lower hepatic FFA uptake compared to the less active group (5.5 +/- 4.3 versus 9.0 +/- 6.1 micromol (100 ml)(-1) min(-1), P = 0.04). Hepatic FFA uptake associated significantly with body fat percentage (P = 0.05). Myocardial FFA uptake was similar between the groups. In conclusion, in the absence of the confounding effects of genetic factors, moderately increased physical activity and aerobic fitness decrease body adiposity even in normal-weighted healthy young adult men. Further, increased physical activity together with decreased intra-abdominal adiposity seems to decrease hepatic FFA uptake but has no effects on skeletal muscle or myocardial FFA uptake. |
| Databáze: | OpenAIRE |
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