In situplasma fabrication of ceramic-like structure on polymeric implant with enhanced surface hardness, cytocompatibility and antibacterial capability
| Autor: | Jun Liu, Junhui Ji, Paul K. Chu, Wang Gexia, Haigang Shi, Pingli Wang, Kun Yang, Wei Zhang |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Biocompatibility Silicon Biomedical Engineering chemistry.chemical_element Nanotechnology 02 engineering and technology 01 natural sciences Biomaterials 0103 physical sciences Ceramic Elastic modulus 010302 applied physics chemistry.chemical_classification Metals and Alloys Substrate (chemistry) Polymer 021001 nanoscience & nanotechnology Hardness chemistry Chemical engineering visual_art Ceramics and Composites visual_art.visual_art_medium 0210 nano-technology Antibacterial activity |
| Zdroj: | Journal of Biomedical Materials Research Part A. 104:1102-1112 |
| ISSN: | 1549-3296 |
| DOI: | 10.1002/jbm.a.35652 |
| Popis: | Polymeric materials are commonly found in orthopedic implants due to their unique mechanical properties and biocompatibility but the poor surface hardness and bacterial infection hamper many biomedical applications. In this study, a ceramic-like surface structure doped with silver is produced by successive plasma implantation of silicon (Si) and silver (Ag) into the polyamine 66 (PA66) substrate. Not only the surface hardness and elastic modulus are greatly enhanced due to the partial surface carbonization and the ceramic-like structure produced by the reaction between energetic Si and the carbon chain of PA66, but also the antibacterial activity is improved because of the combined effects rendered by Ag and SiC structure. Furthermore, the modified materials which exhibit good cytocompatibility upregulate bone-related genes and proteins expressions of the contacted bone mesenchymal stem cells (BMSCs). For the first time, it explores out that BMSCs osteogenesis on the antibacterial ceramic-like structure is mediated via the iNOS and nNOS signal pathways. The results reveal that in situ plasma fabrication of an antibacterial ceramic-like structure can endow PA66 with excellent surface hardness, cytocompatibility, as well as antibacterial capability. |
| Databáze: | OpenAIRE |
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