The Effects of the Organic Flame-Retardant 1,2-Dibromo-4-(1,2-dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines
| Autor: | John E. Elliott, Tony D. Williams, Timothy V. Beischlag, Lilian I. L. Wong, Heidi A. Currier, Michael E. Cox, Alexandra R. Reers |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.drug_class Health Toxicology and Mutagenesis 010501 environmental sciences urologic and male genital diseases Toxicology 01 natural sciences Biochemistry Partial agonist 03 medical and health sciences Antigen Internal medicine LNCaP medicine Molecular Biology 0105 earth and related environmental sciences Messenger RNA Chemistry General Medicine Androgen Androgen receptor 030104 developmental biology Endocrinology Endocrine disruptor Cancer research Molecular Medicine Fire retardant |
| Zdroj: | Journal of Biochemical and Molecular Toxicology. 30:239-242 |
| ISSN: | 1095-6670 |
| DOI: | 10.1002/jbt.21784 |
| Popis: | The effects of the organic flame retardant 1,2-Dibromo-4-(1,2-dibromoethyl) cyclohexane (TBECH) on androgen receptor target gene expression were examined in the human LNCaP prostate cancer cell line. While γ-/δ-TBECH alone led to a significant increase in prostate-specific antigen (PSA) mRNA accumulation, both the α-/-TBECH and γ-/δ-TBECH mixtures repressed androgen-inducible PSA mRNA and protein accumulation in human LNCaP cells. Thus, we hypothesize that isomeric mixtures of TBECH may act as partial agonists of the androgen receptor. |
| Databáze: | OpenAIRE |
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