Quantitative computed tomography assessment of transfusional iron overload
| Autor: | Aakansha Gera, Vicente Gilsanz, John C. Wood, Thomas D. Coates, Ashley O. Mo, Montre Koh |
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| Rok vydání: | 2011 |
| Předmět: |
musculoskeletal diseases
Liver Iron Concentration medicine.medical_specialty medicine.diagnostic_test business.industry Beta thalassemia Magnetic resonance imaging Hematology Mri studies medicine.disease body regions medicine In patient Tomography Radiology Siderosis Quantitative computed tomography business Nuclear medicine |
| Zdroj: | British Journal of Haematology. 153:780-785 |
| ISSN: | 0007-1048 |
| DOI: | 10.1111/j.1365-2141.2011.08590.x |
| Popis: | Quantitative computed tomography (QCT) has been proposed for iron quantification for more than 30 years, however there has been little clinical validation. We compared liver attenuation by QCT with magnetic resonance imaging (MRI)-derived estimates of liver iron concentration (LIC) in 37 patients with transfusional siderosis. MRI and QCT measurements were performed as clinically indicated monitoring of LIC and vertebral bone-density respectively, over a 6-year period. Mean time difference between QCT and MRI studies was 14 d, with 25 studies performed on the same day. For liver attenuation outside the normal range, attenuation values rose linearly with LIC (r(2) = 0·94). However, intersubject variability in intrinsic liver attenuation prevented quantitation of LIC |
| Databáze: | OpenAIRE |
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