Pharmacosomes as Drug Delivery System: An Overview
| Autor: | Nikita D. Gidde, Shrinivas K. Mohite, Indrayani D. Raut, Manojkumar M. Nitalikar, Chandrakant S. Magdum |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Asian Journal of Pharmaceutical Research. :122-127 |
| ISSN: | 2231-5691 2231-5683 |
| DOI: | 10.52711/2231-5691.2021.00023 |
| Popis: | Pharmacosomes are the colloidal dispersions of drugs covalently bound to lipids and can exist, depending on the chemical structure, as ultrafine vesicular, micellar, or hexagonal aggregates. Because of the linking of a drug (pharmakon) to a carrier (soma), they are rightly termed "pharmacosomes."Pharmacosomes can be characterized as a neutral molecule with both positive and negative charges, water-loving and fat-loving characteristics, and in complex form, an ideal polyphenol-to-phospholipid ratio. Pharmacosomes are amphiphilic lipid vesicular systems that have demonstrated their ability to increase the bio-accessibility of poorly water-soluble and poorly lipophilic medicines. Drug pharmacosomes provide an effective method of delivering the drug directly to the infection site, which contributes to a lowering in drug toxicity without harmful effects, and also lowers the cost of therapy by improving the drug's bioavailability, particularly in the case of poorly soluble drugs. Pharmacosomes are appropriate to incorporate both hydrophilic and lipophilic drugs. Pharmacosomes have been designed for multiple anti-inflammatory medications that are non-steroidal, neurological, and antineoplasty. |
| Databáze: | OpenAIRE |
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