Antioxidant and Anti-Inflammatory Activities of Dihydroquercetin, its Aminomethylated Derivative, and their Inclusion Complexes with Cyclodextrin

Autor:	A. I. Matyushin, A. O. Pozdeev, V. V. Knyazev, M. P. Koroteev, A. M. Koroteev, N. L. Shimanovsky, V. S. Rogovskii
Rok vydání:	2021
Předmět:	Pharmacology chemistry.chemical_classification Antioxidant Cyclodextrin medicine.drug_class medicine.medical_treatment Pharmacology toxicology Medicinal chemistry Anti-inflammatory chemistry.chemical_compound Diclofenac chemistry Drug Discovery medicine Taxifolin Derivative (chemistry) medicine.drug Paw edema
Zdroj:	Pharmaceutical Chemistry Journal. 55:778-780
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-021-02493-y
Popis:	The antioxidant properties of dihydroquercetin (DHQ, taxifolin), its aminomethylated derivative (KH-14), and their inclusion complexes in cyclodextrin were compared. The results indicated that DHQ and KH-14 had comparable antioxidant activities. The antioxidant activities of DHQ and KH-14 were preserved upon formation of the inclusion complexes in cyclodextrin. Taxifolin, KH-14, and the water-soluble inclusion complex of KH-14 in cyclodextrin at a dose of 0.04 mmol/kg exhibited pronounced anti-inflammatory effects on the model of carrageenan-induced paw edema in mice that were equivalent to that of diclofenac at a dose of 0.02 mmol/kg.
Databáze:	OpenAIRE
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