Determinants of alpha-fetoprotein levels in patients with hepatocellular carcinoma: Implications for its clinical use

Autor: Edoardo G. Giannini, Francesco Giuseppe Foschi, Marco Zoli, Mariella Di Marco, Rodolfo Sacco, Roberto Virdone, Gabriele Missale, Gian Lodovico Rapaccini, Giorgio Sammito, Filomena Morisco, Eugenio Caturelli, Franco Borzio, Fabio Farinati, Martina Felder, Giuseppe Cabibbo, Franco Trevisani, Gianluca Svegliati Baroni, A. Pecorelli, Francesca Ciccarese, Antonio Gasbarrini
Rok vydání: 2014
Předmět:
Zdroj: Cancer. 120:2150-2157
ISSN: 0008-543X
DOI: 10.1002/cncr.28706
Popis: BACKGROUND α-Fetoprotein (AFP) is a biomarker commonly used in the management of patients with hepatocellular carcinoma (HCC), although the possible determinants of its serum levels in these patients have not been adequately explored. For this study, the authors evaluated the relevance of demographic, clinical, and oncologic factors to the presence of elevated AFP levels in large cohort of patients with HCC. METHODS In 4123 patients with HCC who were managed by the Italian Liver Cancer Group, AFP levels were assessed along with their association with demographic, biochemical, clinical, and oncologic characteristics. Patients were subdivided according to the presence of elevated AFP (ie, >10 ng/mL). RESULTS AFP levels were elevated in 62.4% of patients with HCC. Multivariate logistic regression analysis indicated that being a woman (odds ratio [OR], 1.497; 95% confidence interval [95%CI], 1.250-1.793; P 2 cm (OR, 1.346; 95% CI, 1.135-2.596; P = .001), multinodular HCC (OR, 1.641; 95% CI, 1.403-1.920; P
Databáze: OpenAIRE
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