Adjuvant Properties of Cytokines in Vaccination (Review)

Autor:	Zh. I. Avdeeva, N. V. Medunitsyn, N. A. Alpatova, T. N. Nikitina
Rok vydání:	2020
Předmět:	Pharmacology Protective immunity Immune status Chemistry medicine.medical_treatment Pharmacology toxicology Immunoadjuvant Vaccination Immune system Antigen Drug Discovery Immunology medicine Adjuvant
Zdroj:	Pharmaceutical Chemistry Journal. 53:991-996
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-020-02111-3
Popis:	Vaccinal prophylaxis is the most effective way to reduce incidence rates. However, the immune response developing after injection of most inactivated vaccines is insufficient when used without adjuvants. Special attention should be paid to the issue of immunoprophylaxis of high-risk patients with impaired immune status. Use of appropriate adjuvants during vaccination can optimize development of protective immunity in immunocompromised patients. Cytokines that regulate in vivo immune-response cascades to any antigenic stimulus and influence the development of an antigen-specific immune response can be considered as potential immunoadjuvants. The present review analyzes briefly studies of the immunoadjuvant properties of cytokines used to increase the effectiveness of regularly scheduled vaccines and those used for epidemic indications.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::39c89c20ac6b697a5047b7ef54668785 https://doi.org/10.1007/s11094-020-02111-3 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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