Piroxicam ex vivo release kinetics from zein/pectin delivery systems

Autor:	Z. K. Mukhidinov, I. F. Rakhimov, L. S. Liu, G. F. Kasymova, D. T. Bobokalonov, F. M. Khodzhaeva
Rok vydání:	2012
Předmět:	Pharmacology Drug food.ingredient Chromatography Pectin Chemistry media_common.quotation_subject Kinetics Piroxicam Biodegradable polymer Bioavailability food Drug Discovery Drug delivery medicine Ex vivo medicine.drug media_common
Zdroj:	Pharmaceutical Chemistry Journal. 46:378-380
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-012-0803-3
Popis:	Piroxicam ex vivo release kinetics from zein/pectin drug delivery systems were studied using rat cecum. The piroxicam release kinetic parameters were calculated using a first-order equation and the Peppas equation. The results indicated that diffusion of the therapeutic agent was the rate-limiting step in piroxicam release from the hydrogel microspheres. The created therapeutic drug forms based on biodegradable polymers were an alternative to the peroral administration of most drugs with limited bioavailability.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::396edfce2d7d42a12d506685f15dc42d https://doi.org/10.1007/s11094-012-0803-3 Zobrazit plný text záznamu Plný text ve formátu PDF