Nanoparticle structure transformation of mPEG grafted chitosan with rigid backbone induced by α-cyclodextrin
| Autor: | Kaiyan Lou, Xinyu Hou, Lei Huang, Feng Gao, Jiaojiao Chen, Muye He, Yiben Lu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Materials science Cyclodextrin Nanoparticle 02 engineering and technology General Chemistry Polyethylene glycol 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Micelle 0104 chemical sciences chemistry.chemical_compound chemistry Chemical engineering PEG ratio Copolymer Zeta potential Particle size 0210 nano-technology |
| Zdroj: | Chinese Chemical Letters. 30:163-166 |
| ISSN: | 1001-8417 |
| DOI: | 10.1016/j.cclet.2017.12.012 |
| Popis: | This paper presented an interesting nanoparticle-based drug delivery system with morphology transition behavior depending on the content of exposed PEG chain on the particle surface, which is adjustable by addition of different amount of cyclodextrin (α-CD). The effect of α-CD inclusion to the self-assembly behavior of methoxy polyethylene glycol (mPEG) grafted chitosan (CS) was studied. The results showed that the mPEG grafted chitosan (mPEG-g-CS) forms self-assembled nanoparticles with either micelle or hollow sphere morphology depending on the ratio of α-CD to mPEG, as characterized by atomic force microscopy (AFM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). Their sizes and zeta potential increased from 257.6 nmto 768.2 nm and from +4.5 mV to +11.6 mV, respectively, with the increasing amount of α-CD. The correlation between zeta potential and particle size of α-CD/mPEG-g-CS nanoparticles indicated varied PEG density on surface of nanoparticles. Based on the above experimental observations, a likely mechanism for the morphological transition of the rod-coil graft copolymer mPEG-g-CS was proposed. |
| Databáze: | OpenAIRE |
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