Multiple neoplasms in an adolescent child associated with IgA deficiency

Autor:	William A. Newton, H. William Clatworthy, Inta J. Ertel, Charles B. Reiner, Ala B. Hamoudi
Rok vydání:	1974
Předmět:	Cancer Research Malignant Thymoma Pathology medicine.medical_specialty business.industry Meninges medicine.disease Spinal column digestive system diseases Lymphoma Malignant transformation medicine.anatomical_structure Oncology Scalp Medicine Adenocarcinoma business Multiple Adenomatous Polyps
Zdroj:	Cancer. 33:1134-1144
ISSN:	1097-0142 0008-543X
DOI:	10.1002/1097-0142(197404)33:4<1134::aid-cncr2820330437>3.0.co;2-7
Popis:	A report is presented of an unusual occurrence of multiple primary malignant neoplasms in a young girl. Beginning at the age of 10 she had multiple adenomatous polyps removed from the colon over a 2-year period. One of the polyps had a malignant transformation. During the ensuing 8 years, she developed malignant thymoma, squamous cell carcinoma of the scalp, adenocarcinoma of the colon, which recurred, and choroid tumor of the eye. She died at the age of 20 with malignant astrocytoma of the cerebrum. A brother died at the age of 16 because of lymphoma, lymphocytic, well differentiated, with invasion of the spinal column and meninges. The girl had a serum IgA less than 20% of normal level and her brother had total absence of IgA.
Databáze:	OpenAIRE
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