Long-Term Outcome after Bone Marrow Transplantation for Adult Thalassemia

Autor:	Paola Polchi, Javid Gaziev, Aldo Montuoro, Pietro Sodani, Andrea Roveda, Buket Erer, Maria Domenica Simone, Guido Lucarelli, Luca Spitaleri
Rok vydání:	2005
Předmět:	Pediatrics medicine.medical_specialty business.industry Thalassemia Immunology Management of thalassemia Cell Biology Hematology Transplant-Related Mortality medicine.disease Biochemistry Sickle cell anemia Fludarabine Transplantation Regimen Toxicity medicine business medicine.drug
Zdroj:	Blood. 106:2031-2031
ISSN:	1528-0020 0006-4971
DOI:	10.1182/blood.v106.11.2031.2031
Popis:	Advances in management of thalassemia have increased the proportion of patients living into adulthood. However, disease and treatment related complications in these patients progress over time causing severe morbidity and shortened life expectancy even in well-resourced countries with universal access to good medical treatment. Adult thalassemics constitute a high risk group of patients for transplantation due to both advanced age and acquired multiple organ damage. We present here long-term outcome after BMT for adult thalassemia and a new approach to transplant adult patients. Between November 1988 and September 1996, 107 consecutive patients (median age 22 years; range 17–35) received BMT from HLA-identical related donors following BU14/16 CY120/160 regimen. There were 18 class 2 and 89 class 3 patients. The probability of overall survival, event-free survival, mortality and rejection were 66%, 62%, 37% and 4% respectively. Interestingly, unlike class 3 younger patients (age
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::39234c4aa4228c6f9a8a0e540b0d8478 https://doi.org/10.1182/blood.v106.11.2031.2031 Zobrazit plný text záznamu