Molecular mediators of Porphyromonas gingivalis -induced T-cell apoptosis

Autor:	Roy R. B. Russell, J. I. Harris, John J. Taylor, J. Aduse-Opoku, M. A. Curtis
Rok vydání:	2002
Předmět:	Microbiology (medical) Programmed cell death Proteases Protease biology medicine.medical_treatment Immunology Virulence biology.organism_classification Microbiology Jurkat cells Immune system Apoptosis medicine General Dentistry Porphyromonas gingivalis
Zdroj:	Oral Microbiology and Immunology. 17:224-230
ISSN:	0902-0055
Popis:	Porphyromonas gingivalis produces virulence factors which can modify the molecular and cellular components of the host immune response. In the present work we investigated the role of specific virulence factors from P. gingivalis in the induction of apoptosis in Jurkat T cells. P. gingivalis culture supernatants mimicked the effect of butyric acid on T-cell apoptosis and this effect was associated with an increase in histone H4 acetylation. A role for proteases was excluded in experiments which demonstrated that neither protease inhibitors nor use of P. gingivalis mutants defective in protease synthesis had any effect on the stimulation of T-cell apoptosis in this system.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::38d6cdbac82e1aded758d84123a77572 https://doi.org/10.1034/j.1399-302x.2002.170404.x Zobrazit plný text záznamu Plný text