Ligand-Enabled Pd(II)-Catalyzed C(sp3)–H Lactonization Using Molecular Oxygen as Oxidant
| Autor: | Minyan Li, Jennifer X. Qiao, Jason S. Chen, Jin-Quan Yu, Jeremy M. Richter, Martin D. Eastgate, Shaoqun Qian, William R. Ewing, Zi-Qi Li, Steven R. Wisniewski |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
010405 organic chemistry
Ligand Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Oxygen Nitrogen 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Molecular oxygen Physical and Theoretical Chemistry Benzoic acid |
| Zdroj: | Organic Letters. 22:3960-3963 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.0c01243 |
| Popis: | Pd(II)-catalyzed C-H lactonization of o-methyl benzoic acid substrates has been achieved using molecular oxygen as the oxidant. This finding provides a rare example of C-H oxygenation through Pd(II)/Pd(0) catalysis as well as a method to construct biologically important benzolactone scaffolds. The use of a gas mixture of 5% oxygen in nitrogen demonstrated the possibility for its application in pharmaceutical manufacturing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|