Kinetics of acoustic release of doxorubicin from stabilized and unstabilized micelles and the effect of temperature

Autor:	Emad O. AlAqqad, Mario A. Diaz de la Rosa, William G. Pitt, Abdullah Al Baik, Yaman Kadimati, Ghaleb A. Husseini, Saif Al Mamary
Rok vydání:	2011
Předmět:	Polymeric micelles Computer Networks and Communications Chemistry Applied Mathematics Significant difference Kinetics Poloxamer Micelle Reaction rate constant Chemical engineering Control and Systems Engineering Chemotherapy Drugs Signal Processing medicine Doxorubicin medicine.drug
Zdroj:	Journal of the Franklin Institute. 348:125-133
ISSN:	0016-0032
DOI:	10.1016/j.jfranklin.2009.02.007
Popis:	Ultrasound is being investigated as a trigger mechanism to deliver high concentrations of chemotherapy drugs to cancerous tissues using polymeric micelles. In this paper, we examined the kinetics of acoustic release of doxorubicin using stabilized and non-stabilized micelles. Kinetic models were used to regress release and re-encapsulation time constants for three different compounds, namely non-stabilized Pluronic ® P105 micelles, P105 micelles stabilized using an interpenetrating network of N,N-diethylacrylamide and micelles formed by PEO-b-poly(NIPAAm-co-HEMA-lactate n ). Results showed that the kinetic release constant ( k r ) depends on the micellar system under investigation. On the other hand, there is no statistically significant difference between re-encapsulation rate constants for stabilized and unstabilized micelles. We hypothesize that k r depends on the degree of cross-linking or stabilization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::38762da7634cdd4b00d04580a3dc65e7 https://doi.org/10.1016/j.jfranklin.2009.02.007 Zobrazit plný text záznamu Full Text from ScienceDirect