Effect of the Melatonin on Morning Blood Pressure Surge and Norepinephrine Endovenous Infusion in Healthy Volunteers
| Autor: | Sonia María López-Correa, Jaime Carranza-Madrigal, José Miguel Cervantes-Alfaro |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
endocrine system
medicine.medical_specialty business.industry Placebo Crossover study Norepinephrine (medication) Melatonin Pineal gland Endocrinology medicine.anatomical_structure Blood pressure Internal medicine Anesthesia Heart rate medicine business hormones hormone substitutes and hormone antagonists Morning medicine.drug |
| Zdroj: | International Journal of Clinical Medicine. :458-464 |
| ISSN: | 2158-2882 2158-284X |
| DOI: | 10.4236/ijcm.2015.67060 |
| Popis: | Melatonin, the pineal gland hormone, has been considered as a central hypotension factor. However their roles in the regulation of the human blood pressure and its possible use as antihyper-tensive drug have not been fully determined. The objective of this trial was to determine the effect of melatonin on blood pressure morning increase and a peripheral vasoconstriction challenge in healthy volunteers. Twelve healthy male volunteers were included in a prospective, comparative, randomized, crossover trial in which changes on blood pressure (BP) and heart rate (HR) after the first morning orthostatism and endovenous norepinephrine (NE) infusion were measured one hour after the administration of placebo (PL) or 10 mg of melatonin in double blind conditions. Melatonin blunted the effects of the first orthostatism on BP and HR. Melatonin also reduces the pressor effect of NA. One concludes that melatonin has central and peripheral hypotensive effects that support a potential role of this hormone in cardiovascular therapeutics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|