Reduced Intensity Conditioning (RIC) Transplantation In Acute Leukemia: The Effect of Source of Unrelated Donor Stem Cells on Outcomes
| Autor: | Claudio Brunstein, Mary Eapen, Kwang w Ahn, Frederick R. Appelbaum, Karen K Ballen, Richard Champlin, Fangyu Kan, Mary J. Laughlin, Robert J Soiffer, Daniel J. Weisdorf, Ann Woolfrey, Mary M. Horowitz, John E. Wagner |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Blood. 116:908-908 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v116.21.908.908 |
| Popis: | Abstract 908 Peripheral blood progenitor cells (PBPC) are the preferred graft source for RIC transplantation. As in other settings, if a suitable unrelated adult donor is not available, primarily HLA mismatched unrelated cord blood (CB) is increasingly utilized, including the co-infusion of two CB units to overcome the cell dose limitation. We here report the relative efficacy of double CB (dCB, n=161) transplantation vs. PBPC whether from an 8/8 HLA matched (MUD, n=313) vs. 1 allele mismatched (MMUD, n=111) unrelated donor in patients with acute myeloid (AML, n=523) and lymphoblastic leukemia (ALL, n=62) transplanted between 2000 and 2009. Patients were aged 21 – 69 years. dCB recipients were more likely to be younger (median age: 54 vs. MUD 59 vs. MMUD 58 years, p Grade 2–4 Acute GVHD* Chronic GVHD* TRM Relapse† Treatment failureμ Overall mortalityμ MUD vs. dCB after TCF HR 0.52 p=0.0001 HR 2.33 p=0.0001 HR 1.09 p=0.72 HR 0.79 p=0.15 HR 0.89 p=0.37 HR 0.93 p=0.60 MMUD vs. dCB after TCF HR 0.70 p=0.06 HR 2.22 p=0.0002 HR 1.77 p=0.04 HR 0.87 p=0.49 HR 1.14 p=0.43 HR 1.15 p=0.41 dCB after TCF vs. dCB after other RIC HR 1.64 p=0.09 HR 0.61 p=0.11 HR 0.34 p Disclosures: No relevant conflicts of interest to declare. |
| Databáze: | OpenAIRE |
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